Magic Methyl Effect: Transition Metal Catalyzed

Magic Methyl Effect: Transition Metal Catalyzed The insertion of a methyl group, the smallest alkyl group, into a C-H bond has been shown to enhance such pharmacological charactistics as bioavailability and potency.1 Traditionally, incorporation of a methyl group into a bioactive compound has required lengthy de novo synthesis. Consequently, synthetic reactions that allow late-stage installation of methyl groups into advanced intermediates are of great potential value in the pharmaceutical industry. In the past two decades interest in directed C−H activation followed by the methylation led to the development of strategies which use precious metals catalysts forarenes ortho-functionalizations.2, 3 Currently, only a few reactions exist which enable such transformations to be achieved in a single step,1, 4 highlighting the difficulty in converting a C-H bond to C-Me bond. Most of these methods require heavy loadings of precious metal catalysts to obtain the desired methylated product (Scheme 1).4 Moreover, some of them use hazardous and toxic methylating reagents1 with strongly basic reaction media what results in a limited scope1,4 and the uncontrolled formation of both mono- and dimethylated products.2 This reflects the need for new methylation methods which will overcome mentioned limitations. Scheme 1. Ortho-methylation with precious metal To address the toxicity and expense of the precious metal catalysis, first row metal-catalyzed C−H functionalization has recently been recognized as a straightforward and a powerful tool for the formation of Csp2 Csp3 bonds in modern organic synthesis. In addition first row transition metals introduce interesting mechanistic possibilities for ortho-methylation; they are readily available and relatively low toxicity.1, 4 Recently Lu and co-workers reported the cobalt (II)-catalyzed direct C-H methylation of unactivated (hetero)arenes using dicumyl peroxide (DCP) as the methyl source, base and most importantly as an oxidant. Cobalt mediated C-H functionalization is a maturing field; however, there exist only two examples of its application to methylation of aromatics, using N-methyl-1-naphthamide and benzo[h]quinolone substrates respectively. The reaction proved to be mild, functional group tolerant and uses a less toxic methylating reagent. The paper reports effective access to a range of ortho-methylated (hetero)aromatic carboxamides (Scheme 2).5 Scheme 2. Ortho-methylation with cobalt catalysts Chatani and co-workers reported the use of aryltrimethylammonium bromide and iodide as new methylating reagents in conjunction with nickel-catalyzed C-H bond activation (Scheme 3). Changing from a palladium6 catalyst to nickel makes the ammonium salt act as a methyl source rather than aryl source for a range of 8-aminoquinoline aryl amides. Unfortunately harsh conditions make it difficult to control the selectivity between mono- and dimethylation at the ortho positions in some cases.7 Scheme 3. Ortho-methylation with nickel catalyst using aryltrimethylammonium iodide as methylating reagent Nakamura and co-workers have reported two separate iron-catalyzed conditions seemingly solving a lot of issues associated with the previous examples. The direct C-H methylation reaction with a picolinoyl or 8-aminoquinolyl directing groups, an iron/diphospine catalyst, and inexpensive 2,3-dichlorobutane as an oxidant furnished an efficient, robust reaction (Scheme 4).8 Unfortunately the method relies upon superstoichiometric methyl equivalents in the form of the pyrophoric trimethylaluminum. Scheme 4. Ortho-methylation with iron catalyst using trimethylaluminum as methyl source Nakamura and co-workers further optimized the iron-catalyzed C-H methylation reaction by screening ligands.9 The tridentate phosphine ligand NMe2-TP in combination with Fe(acac)3 catalyzed the ortho C-H methylation of simple aromatic carbonyl compounds without requiring additional directing groups. This reaction showed wide substrate generality, functional group tolerance, and resistance to catalytic poisons taking advantage of functional groups inherent to the advanced intermediates (Scheme 4).9 This seminar will discuss the scope and limitations of these recently published methods, and assess the progress towards developing general solutions to the challenge of late-stage methyl incorporation. References: Schà ¶nherr H., Cernak T. Angew. Chem. Int. Ed. 2013, 52, 12256 Lyons T. W., Sanford M. S. Chem. Rev. 2010, 110, 1147 Snieckus V. Chem. Rev. 1990, 90, 879 Yan G., Borah A. J., Wang L. and Yanga M. Adv. Synth. Catal. 2015, 357, 1333 Li Q., Li Y., Hu W., Hu R., Li G. and Lu H. Chem. Eur. J. 2016, 22, 12286 Zhu F., Tao J.-L., Wang Z.-X. Org. Lett. 2015, 17, 4926 Uemura T., Yamaguchi M., and Chatani N. Angew. Chem. Int. Ed. 2016, 128, 3214 Shang R., Ilies L, and Nakamura E. J. Am. Chem. Soc. 2015, 137, 7660 Shang R., Ilies L. and Nakamura E. J. Am. Chem. Soc. 2016, 138, 10132 Minds, Brains And Programs: Analysis Minds, Brains And Programs: Analysis Searle is arguing that a computer couldnt understand Chinese. Is this the right way to describe the view that Searle is arguing for in Minds, Brains, and Programs? If not, why not? In his Chinese Room argument, Searle observes that if manipulating Chinese symbols according to formal rules is insufficient for the person to understand Chinese, it is also insufficient for a computer to understand Chinese-both are engaging in mindless symbol manipulation. However, he isnt arguing that a computer couldnt understand Chinese, but rather that their programs themselves cant understand Chinese-symbol manipulation isnt constitutive of or sufficient for minds. Searle is not arguing that computers/machines cant think. In fact, he believes that only a machine can think (namely brains and machines that have the same causal powers as brains); he says that brains are machines, and brains think. However, according to Searle, whether something thinks depends not only on the program that it is running but also its hardware-the nature of the thing running the program. Simply implementing a program that is formally isomorphic to human thought processes, as in the Chinese Room example, is insufficient for intentionality and consequently thought (in this case, understanding Chinese) since a program can be instantiated without mental states-essentially, Searles argument is that formal computations on symbols cannot themselves produce thought. What is the systems response to the Chinese Room argument? Is Searle correct to think that the response begs the question because it assumes that the system understands Chinese? The systems response to the Chinese Room argument acknowledges that the man running the program does not understand Chinese. However, he is a part of a larger system that is comprised of the complete set of components that is necessary for answering the Chinese questions, and which as a whole does understand Chinese. Simply asserting that although the man wouldnt understand Chinese the whole system would, does beg the question. However, Searle is incorrect to think that the complete systems response begs the question-it counters Searles argument by observing that the Chinese room argument is logically invalid, being as its conclusion does not follow logically from its premise. Inferring that the system of which the man is a component does not understand Chinese from the premise that the man himself does not understand Chinese is invalid, because there is no logical connection between the premise and the conclusion. What is the point of Searles Chinese Gym example? What do you think the right response to it is? In his Chinese Gym example, Searle illustrates a hypothetical Chinese gym, populated by monolingual English speakers that follow instructions in English to collectively produce output indistinguishable from that of native Chinese speakers. It is analogous to the Chinese Room example but with more people and involves parallel processing-it can perform many computations at a time. Its purpose is to oppose Strong AI. Searles main argument is that it is self-evident that the only things occurring in the Chinese gym are meaningless syntactic manipulations from which intentionality and subsequently thought could not conceivably arise, both individually and collectively. Using the same method in which Copeland used the systems response to defend Strong AI and respond to the Chinese Room argument, we can respond logically to the Chinese Gym example. In other words, it is invalid to infer that a system (the gym) which consists of entities that dont understand Chinese doesnt understand Chinese, from the simple premise that the entities that comprise the system dont understand Chinese. There is no logical connection between the premise and the conclusion. Question 3 No amount of knowledge of the neural basis of taste experiences (or any other physical information) will enable you to know what Marmite tastes like. Only tasting Marmite can tell you what Marmite tastes like. Why is this an objection to physicalism? Physicalism holds that everything is comprised solely of its physical properties; that is, only physical things exist and everything is explicable in terms of the physical. The Physicalist would argue, for instance, that what it is like for someone to taste Marmite is one and the same as some physical quality-knowing the pertinent physical facts of the taste of Marmite are sufficient for knowing the actual taste of Marmite itself. Therefore the statement in question is an objection to physicalism being as it implies that there arent only physical properties since only tasting Marmite can really tell you what Marmite tastes like-for every experience there exist subjective, phenomenal qualities that one could not know of solely via knowledge, but only through experience. In other words, one will have experiences for which one has no corresponding concept; experiences extend beyond simple, learnable physical qualities. This is an objection to the physicalists argument that for everything in the universe there exist only objective, physical bases for everything in the universe. How would Lewis respond to the argument in (a)? Is this a good response? The argument in (a) is analogous to the Knowledge Argument, which Lewis would respond to with the Ability Argument. His position on (a) is in the middle. He agrees that there are aspects of ability that do not consist simply of information possession, and that we do call knowledge. However, he contrasts possessing a new fact with possessing a new ability-having a new experience does not imbue an individual with any new propositional knowledge, but only a bundle of abilities (to imagine, remember and recognize: know-how). These are abilities you cannot gain except by tasting Marmite, and learning what an experience is like means gaining certain abilities-he is fine with the argument in (a), but simply distinguishes that abilities rather than special phenomenal facts are acquired via experiences. This is a good response because learning what an experience is like means gaining certain abilities but its up for grabs what, if anything, the causal basis for those abilities may represent. There is no proof that tasting Marmite is the only way to know what it tastes like as the experience allows one to acquire special phenomenal facts which cannot be represented in any other way nor taught, other forms of tasting Marmite that lead to the same brain state may exist. What is the hard problem associated with the taste of Marmite, and how does it contrast with easy problems associated with explaining taste experiences? The hard problem questions how and why neural processes lead to certain subjective experiences. In the context of tasting Marmite, it is associated with the subjective experience of the taste of Marmite-facts about conscious experience that cannot be deduced from physical facts about the functioning of the brain. The problem of explaining the subjective taste of Marmite, or why the experience even exists in the way it does, is hard. In other words the hard problem is the problem of explaining why a brain state necessary and sufficient for having the experience of tasting Marmite is correlated with the experience of tasting Marmite and not with some other experience. Here we have no conceptions of how physical goings-on give rise to experiences. This contrasts with the easy problem of experiences, which concerns the objective mechanisms of the cognitive system-everything can be solved or explained in terms of neurological or physical goings-on that stimulate certain responses. In the context of taste experiences, the easy question would state that the experiences come into existence simply when neurotransmitters activate taste buds.

Agriculture In Deforestation And Desertification Environmental Sciences Essay

Agriculture In Deforestation And Desertification Environmental Sciences Essay The World Resources Institute estimates that more than 50 percent of the earths natural forests have already been destroyed (Hermosilla 2000). The United Nations Environment Programme (2009) states that forests cover 30 per cent of the planets total land area. The total forested area in 2005 was just under 4 billion hectares As a result a United Nations report has stated that deforestation and forest degradation are widely recognized as one of the most critical environmental problems facing human society, with serious long-term economic, social and ecological consequences (UN 1999). The causes of deforestation are widely debated and are attributed to many causes such as over population and urbanisation such as new settlements and transport extensions (Geist and Lambin, 2002). However one of the main causes of deforestation is attributed to agriculture. The arc of deforestation along the southern and eastern extent of the Brazilian Amazon is the most active land-use frontier in the world in terms of total forest loss (Morton et al, 2006) and Globally, the main forest conversion process in the humid tropics was the transformation of closed, open, or fragmented forests to agriculture (Achard et al 2002). Deforestation originally occurred on a small scale level due to subsistence farming or timber collection. However the Amazon rain forest has seen a recent increase in industrial agriculture intensive mechanized agriculture in the Brazilian Amazon grew by >3.6 million hectares during 2001-2004 (Morton et al, 2006) and this has been a significant source of deforestation in recent years. In 2010 cattle are projected to be grazing on some 24million hectares of Neotropical land that was once forest in 2000 (Wassenaar et al, 2006). Figure 1 shows the causes of Amazonian deforestation from 2000- 2005. The pie chart shows that cattle ranching, a part of agriculture is the main cause of deforestation. Cattle ranching accounts for 65-70% of deforestation; vast areas of land are cleared by commercial farmers to raise cattle (for meat and dairy) and to provide pasture land for the cattle to graze. Moreover another major cause of deforestation is small scale agriculture by subsistence farmers. Subsistence farmers are causing deforestation because of poor practices (Butler 2008). Farmers burn the trees to clear them, and then over-exploit the land causing the soil quality to decline which results in the farmers having to find new land (shifting cultivation) and thus destroy more trees. In addition government policies can lead to deforestation. In Brazil the government allows farmers to claim a piece of unclaimed public land which they must use for over a year; and after 5 years they become the official owners of the la nd and so can sell it and claim new land (Butler 2008). In addition population growth and subsequent food demand is also a cause for expanding agriculture. Figure 1. (Butler, 2008) However research has also shown that agriculture is not the main cause or contributor to deforestation. Instead the main cause of deforestation if attributed to population growth, and its subsequent need to find new land for settlements to be built on. Myers, 1984 says that the main reason for deforestation in the tropics is human population growth. In the African and Asian tropics, it is generally associated with high rates of natural increase (i.e., high net rates of population growth due to high fertility) and, in the Amazon, it is assumed to be the high rates of in-migrationà ¢Ã¢â€š ¬Ã‚ ¦ followed by subsequent intergenerational high rates of natural increase. In addition another primary cause of deforestation, particularly Indonesia is the logging industry. The World Bank (2000) and WRI (2000) state that the leading cause of Indonesian deforestation in the 1990s has been large-scale commercial logging (Palmer 2001). Palmer (2001) continues to say that logging causes areas of forest to be cleared, allowing access to new areas of forest and as a result previously unexploited forest, thus allowing other economic activities such as agricultural conversion and shifting cultivation to take place. Consequently the logging industry can be seen as a major, if not the major contributor to deforestation and not agriculture. Agriculture has been linked to being a cause of desertification, however a variety of other factors are also causes of desertification and a combination or interaction of processes leads to desertification. The United Nations Conference on Environment and Development defines desertification as land degradation in arid, semi-arid, and dry sub-humid areas resulting from various factors, including climatic variations and human activities (UNCCD, 1992) The UNCCD states that Desertification does not refer to the expansion of existing deserts. It occurs because dryland ecosystems, which cover over one third of the worlds land area, are extremely vulnerable to over-exploitation and inappropriate land use. Poverty, political instability, deforestation, overgrazing and bad irrigation practices can all undermine the productivity of the land (UNCCD 2005). Agriculture plays a large role in desertification, the over grazing of land by animals particularly damaging to the soil and is a major factor contributing to desertification; overgrazing is by all measures the principal cause of rangeland degradation (Dregne and Chou, 1992).   Over grazing can occur by having too many animals, or by not managing and controlling the animals grazing activities (Rayburn, 2000). Overgrazing reduces plant leaf areas, which reduces interception of sunlight and plant growth.   Plants become weakened and have reduced root length, and the pasture sod weakensà ¢Ã¢â€š ¬Ã‚ ¦ Overgrazing can increase soil erosion.   Reduced soil depth, soil organic matter, and soil fertility hurt the lands future productivity (Rayburn 2000). Darkoh (2006) highlights that overgrazing in North Africa has led to the desertification of land led to moderate to severe desertification of rangelands in arid and semiarid zones of Algeria, Libya, Morocco and Tunisia Moreover it is not just overgrazing that can lead to soil degradation and desertification. Poor farming techniques such as over exploitation, and constant crop growing without a fallow field can lead to degradation. Arid and semi-arid regions may initially support agriculture, but repeated cultivation frequently leads to a loss of a soils nutrients and water-holding capacity. (Global environmental Governance Project, 2009). Over cultivation removes nutrients from the soil which can lead to the soil becoming derogated and infertile, therefore nothing can grow on it which can lead to soil erosion. In addition to this, poor irrigation systems can lead to salinzation of the soil due to groundwater dissolving salts in the soil. When evaporation takes place, this leaves concentrated amounts of salts in the soil which are toxic to plants and thus the land becomes barren. However agriculture may not be a direct cause of desertification, it can be caused due to knock on effects of population growth and the subsequent increased demand for food. In Africa, a leading cause of desertification is human population pressure which leads to overexploitation and intensified stresses on the natural environment. Africas population has doubled in the past three decades to about 708 million (1994) and continues to expand at a rate of some 3 per cent a year. This means that Africas farmers must feed an additional 21 million people every year (Darkoh, 1998). Moreover population increase can lead to urbanization and more resources being demanded, such as fuel wood which is a common fuel in third world countries; deforestation is also a primary cause of desertification as tree roots bind the soil together, preventing erosion. As a result population pressure has lead to the need for intensive agriculture which can lead to desertification Increased population pressure on the fragile and vulnerable soils of Africas dryland regions, leads to overexploitation of water, land, forest and pasture resources through over cultivation, overgrazing and deforestation. These practices therefore constitute the principal threats to the livelihood of millions of people. These are the foremost causes of soil erosion, the rates of which in Africa are among the highest in the world. (Darkoh,1998). Agriculture plays a large role in deforestation and desertification, but it may not be the main causes of both. Shifting cultivation leads to deforestation as farmers move to new areas of land, often forests which need to be cut down so that the land can be used for agriculture. In addition over grazing and cultivation as well as as poor farming techniques and can lead to desertification. However the real cause of deforestation and desertification can be attributed to government policies and government mismanagement. If governments encourage farmers to seek out new land in the Amazon rain forest, and also do not stop practices of illegal logging. In addition if governments act in their own economic interests and issue policies that lead to environmental harm such as deforestation and desertification then it is not the practices of its people and their techniques (farmers) that cause the damage to the planet, it is the consequence of poor, and often myopic, government policies seeking economic gain; instead of addressing the real causes of the problems of desertification and deforestation. In addition many LEDCs rely on agriculture for economic growth; therefore a balance needs to be met between economic development and sustainability.

Johnny Got His Gun, by Dalton Trumbo :: essays papers

Johnny Got His Gun War in its self is a tragedy. Experiencing the tragedies of war has a life long impact on ones life. In the novel " Johnny got His Gun" by Dalton Trumbo, Joe Bonham is a victim of war and he is forever changed physicaly, mentally and spiritualy. Through Joe it is evident that the price we pay for war is much to high. All people in life have some sort of basic function. Weather it be a parapaliegic who lives alone, goes to work, has some sort of social life, and is a member of a wheelchair basket ball team or a quadrapaliegic who is incapable of doing much but still communicate with friends and family members. Joe is in a terribly worse situation then any of them. Joe spends his days in a hospital bed. He is incapable of any sort of fuction other than moving his head up and down. He can not speak nor can he eat for he has no mouth nor a face. He must be assisted for thing's that a 3 year old child could probably do on their own like changing close or going to the washroom. This predicament, which Joe finds himself in, causes Joe tremendous mental anguish. "Please I can't. Please no. Somebody come. Help me. I can't lie here forever like this until maybe years from now I die. 1 can't. Nobody can. It isn't possible." (Trumbo 3.64) To try to imagine the mental stress which Joe suffers from is unconceivable to any human being. Joe can not distinguish his memories from his consciencnouss nor can he judge if he is awake or asleep. Joe can not communicate with his keepers which is the worst of all his folies "He kept tapping. He kept on now for another reason aside from the simple desire to speak which had started him out. He kept on tapping because he didn't dare stop he didn't dare think. He didn't have the courage to ask himself so simple a question as how long will it be before the nurse understands what I'm doing."(Trumbo 15.180) this causes Joe the most anguish because all he wants now, in his condition, is to go into the world and show everyone the horrors of war. Joe imagines himself in a schoolhouse recitng this nursery rhyme: "Hickory *censored*ory dock my daddy' nuts from shell shock. Humpty dumpty thought he was wise till gas came along and burned out his eyes.

Mending the Transatlantic Rift Essay -- Essays Papers

Mending the Transatlantic Rift The terrorist attacks of September 11, 2001 ushered in an era of dramatic change for foreign policy and the international system. Most obviously, the United States’ sense of invulnerability eroded as an acute awareness to the perils of terrorism gripped the American public. In American foreign policy, the dominant paradigms evolved. Whereas the Cold War notion of the centrality of powerful nation-states had helped order the Bush administration’s outlook before the attacks, the new paradigms explicitly accounted for the importance of non-state actors and rogue regimes as the salient elements of American foreign policy. In emphasizing rogue states, President George W. Bush focused on regime change in Iraq and ultimately decided to invade Iraq despite the opposition of important allies and the lack of authorization from the United Nations Security Council. The war in Iraq, along with an array of diplomatic and policy differences between the United States and its Eur opean allies, ultimately produced notable divisions in the transatlantic relationship. An analysis of the events and conceptual divergences that contributed to this rift renders a portrait of U.S.-European relations in which real rather than cosmetic differences separate the two sides of the Atlantic Ocean. Nonetheless, enduring commonalities and the realities of the present geopolitical situation leave hope for improvements in the relationship. In the end, mending the transatlantic rift will require the United States to exhibit a genuine commitment to diplomacy with Europe and engagement with the world’s most pressing issues. THE RELATIONSHIP Historically, the relationship between the United States and its European allie... ...ember/October 2002. Kagan, Robert. â€Å"America’s Crisis of Legitimacy,† Foreign Affairs, March/April 2004. Mandelbaum, Michael. â€Å"The Inadequacy of American Power,† Foreign Affairs, September/October 2002. The National Security Strategy of the United States of America, September 2002. < http://www.whitehouse.gov/nsc/nss.html> Nye, Jr., Joseph S. â€Å"U.S. Power and Strategy After Iraq,† Foreign Affairs, July/August 2003. O’Hehir, Andrew. â€Å"Welcome to the New Cold War,† Salon.com, November 15, 2004. Pond, Elizabeth. â€Å"European Shock and Awe,† Washington Quarterly, Summer 2003. Project for the New American Century World Press Review. â€Å"We Are All Americans,† November 2001. < http://www.worldpress.org/1101we_are_all_americans.htm>

Dr Jekyll and Mr Hyde Essay -- English Literature

Dr Jekyll and Mr Hyde This novel is more than just a traditional horror story as it has many hidden and complex meanings and explanations, of what seem and would have normally before this book, been simple events. Stevenson has very strong opinions and some are expressed in the book. A traditional horror story would either be a super natural In this novel Stevenson's characters, Jekyll and Hyde, are stereotypes of people who are 'good' and 'evil'. The good is the friendly doctor (the caring profession) and the evil is the hunched, ugly murderer. These two stereotypes combine to create the average man who has the capacity to be both 'good' and 'evil', and they have both 'good' and 'evil' thoughts and emotions. All people have the same emotions, some good and some bad and, like Hyde, when you follow the evil emotions like hate, jealousy and revenge, you are considered evil. Jekyll and Hyde both have these 'evil' emotions but what makes Jekyll 'good' is that he hides them, Jekyll is driven by reason whereas Hyde is driven by desire, he'll do what he wants when he wants. Londonand Jekyll's Houses The street where Jekyll lives is described as merely an anonymous street in London, whose shop fronts "like rows of smiling women" have a brightness that stands out in contrast to the dingy neighborhood. And yet on this street, two doors from the corner, stands a dreary, Gothic house, which "bore in every feature the marks of prolonged and sordid negligence." As we proceed further in the novel, Jekyll's houses will be seen to have their own connection with the characters prosperous, respectable, as well as threatening, mysterious, and sinister. It is clear by each of its two appearances the respectable; Je... ...public has seen only a veneer of my real self." This is true due mostly to the fact that no one knew Mr. Hyde was a part of Dr. Jekyll. Jekyll constantly emphasizes the greatness of his background. He reminds us of his wealthy family, and great education. But he also states "that man is not truly one, but truly two." Dr. Jekyll needed something, or someone to represent the evil which has built up inside of him. He created this through experiments, which lead to a potion. This potion transformed him anytime he wanted. He was transformed into Mr. Hyde. Evil is just a small portion of men, perhaps that is why Mr. Hyde had a dwarfish appearance. The main point was that the potion took over his life, and Dr. Jekyll finally realizes he is unable to transform back into his goodness. He attempts to commit suicide, as this is his only way of destroying Mr. Hyde.

Jerusalem Art Essay

Art involving Jerusalem is very controversial. One has to place into context the fact that Jerusalem is a significant city for three major religions—Islam, Judaism, and Christianity. Having one city be so significant leads to both the creation of conflict and beauty. There is conflict in the sense of war and destruction, and beauty in the sense of art on the subject. The three pieces of art this writer selected were all twentieth century pieces, but all show significant scenes, buildings or represent significant Psalms in the life of Jerusalem. Because of Jerusalem’s historical significance, this writer has chosen a piece of Islamic art that depicts the old city of Jerusalem, a piece of Jewish art that represents the Psalms, and a piece of Christian art that depicts the triumphal entry and some of the significant events of Holy Week, which is the final week of Christ’s life. The first piece of art is an Arab work that shows the old city of Jerusalem. In the painting, one sees a blue-gray sky that overlooks a sandstone colored city. There is a partial wall surrounding the city, and there appears to be two large prayer towers in the background. There are also some people, men, in the picture, looking towards the city and in a couple of cases walking towards that spiritual city. The city appears to be old, but not ancient, which means this is probably dated somewhere around the Crusades. Though this is a contemporary piece, the artist has chosen to depict Jerusalem at its height in Muslim hands. This painting probably represents Jerusalem during the Crusades. This piece would be very inspiring to Muslims, as it shows the city as theirs. It also gives them an image to look to when contemplating their own religious heritage. This brings us to the point of religious iconography and the Islamic faith. Religious iconography does not play as significant a role in Muslim religious life than in other religions. This is due in part to their trepidation about displaying the human form in a religious setting. This writer feels that this piece could be taken a number of different ways depending on the perspective, whether Muslim, Christian, or Jew. For Muslims if would take them back to a time of Muslim supremacy, when they â€Å"owned† one of the most important cities in their religion. Jerusalem is a significant city for the Muslims. According to various scholars, Jerusalem is significant because it is believed it is the city from which Muhammad rose to heaven. It is also significant because some of Islam’s most significant prophets (Abraham and Jesus) preached and taught. It is also a place to which Muhammad made an historic night pilgrimage. For Christians and Jews, it would be a solemn reminder that there was a time when Christians and Jews lost their most holy city to a people they deemed â€Å"infidels†. It would bring about a profound sense of sadness and loss and might inspire a fighting spirit in Jews and Christians to reclaim their city. Over the years, the passions the Muslims have over Jerusalem have become inflamed to the point of outright violence. The attitudes have only gotten more intense and more inflexible towards the Holy City. This writer feels that the times have only served to strengthen the resolve of Muslims to reclaim the city that they perceive as theirs. Emotionally, the tensions in the region have made Muslims even more determined to control the city completely. As significant as Jerusalem is to Muslims, it also has a supreme significance to Jews. Jews actually fee as if the city belongs to them and was bequeathed to them by God thousands of years ago. It is so significant that dozens of Psalms were written about the city. One of the Psalms is 125, which says in part, â€Å"[a]s the mountains surround Jerusalem, so the Lord surrounds His people from this time forth and forever (verse 2). † In this painting by Irv Davis, one sees an encapsulated city of Jerusalem surrounded by grey mountains. The city is cream, almost white, and it is implied that the city is made of marble. The sky is blue and the sun is shining, adding to the shine on the city. One can imply that the encapsulation is the spirit of God surrounding the city and protecting it from outsiders and enemies. The contrasts are very sharp, the darkness of the mountains are contrasted with the whiteness and purity of the city. This obviously represents a very young Jerusalem. This also represents a time when the Jews were extremely fervent about their faith and wished to follow the Lord and seek his will. This picture represents a Jerusalem on the rise. It is also a bit on the allegorical side, with the young city representing a young faith. The newness of the city represents the fervency of the believers. They wish to follow the Lord and, as with anything new, the new city represents a new faith. This piece of art could be taken by the three groups in different ways. For Jews, it represents a time in their history when they had a true passion for God and would write songs of praise to the Lord using their most holy city as an inspiration. For Muslims, it would be a dour reminder that a region and city of the world they felt they originally owned had been forcibly removed from their possession and would remain in control of another group for several thousand years. They would also bemoan the fact that a new faith system would be replacing the polytheism that had dominated the region in the years prior to the Jewish takeover. Jews view the city of Jerusalem with as many passions and emotions as the Muslims. They see it as one of the most significant cities of their faith, and as such, wish to reclaim it as a purely Judeo-Christian city. The emotions of the Jews towards the city have always been strong, but over time, have waxed and waned, leading to the times that we have now where the Jews are fighting as passionately for the city as their Muslim counterparts. Both groups have legitimate religious and traditional claims to the city, yet either refuses to give in and relent towards their passions for the city. They each want the city, and are willing to do just about anything to get and maintain control over it. Christians have a whole other unique perspective on the city of Jerusalem. Before we can discuss the artistic expression of the selected artwork, it bears discussing the cultural ties that bind Christians to the city of Jerusalem. Christians view the city as very important because not only did Jesus make his triumphal entry into the city during Holy Week, but also taught in the region. Additionally, the apostles taught in the region and it was from the city of Jerusalem that Christianity was established in the form of Christ’s death and resurrection. The piece of art that was selected was some hand painted tiles from Jerusalem that show scenes from the triumphal entry and major scenes from Holy Week. The tiles are well-painted and detailed. Though they are also twentieth century, the story they tell condenses the entire story of Christianity in four small tiles. They are done in yellows, blues, white, black, and red. These tiles show an older, wiser Jerusalem. There is an overall sadness to the scenes, when one places the tiles in the context of the Bible, one can find that there is indeed a sadness, but at the same time a joy in the scene being depicted. It is ironic that death represents life and birth, but that is indeed what this scene and this depiction of Jerusalem shows. For Christians, Jerusalem represents the birth of their religion and the new life that is promised from the rising from the dead of Christ. Though there may be other cities that are significant in Christendom, for Christians, the events that transpired the week of Holy Week in Jerusalem are what assured the promises made in all the other cities. This piece of art could be taken by the three religions in different ways. For Christians, obviously, there is an association with the outright birth of the religion. The death that occurred outside Jerusalem represented the birth of a whole new belief system. For Jews, while the beliefs of Christian might be unusual, would see Christians as having as legitimate a claim to the city as they do, since they feel that the two groups worship the same God. For Muslims, the scenes simply show significant scenes in the life of a major prophet of their faith. They may view the Christian’s claims towards the city as interesting, but not as significant nor as important as their own claim towards the city. Christian attitudes towards the city have always been passionate, and they actually fought seven crusades that were specifically designed to take back the city from the Muslims. While they were not successful for long in keeping the Muslims out, they were able to develop a life of â€Å"peaceful coexistence† with the Muslims. Christians traditionally have supported the Jewish claim towards the city, as evidenced in the fact that we actively support the mission of Israel today. Christian passions have always been high for the city, but they have cooled over time, and we no longer actively seek to crusade against those we perceive as infidels. Christians now instead seek peaceful coexistence with other groups, but especially the Muslims. Christians are a pragmatic people that see the realities of the situation and only seek to have the best possible outcomes for all the parties. As one can see from the above statements, Jerusalem holds a special place in the hearts of all three religions. While it has inflamed passions, it has also inspired Psalmists and believers for centuries. We should seek understanding of the situations that create the passions and instead of seeming to remain in a state of constant conflict. We should view Jerusalem as a source of inspiration and not as a source of contention. The world’s three largest religions each have legitimate claims to the city and each needs to give up something in order to get access to the one city that they all deem to be the most important in their religion. The city is a true test of negotiation and faith, and as such should remain a source of inspiration. Bibliography about. com, â€Å"Painting of Jerusalem Psalms. † Judaism. 2000. 19 Apr 2009 . (picture URL) about. com, â€Å"Painting of Jerusalem Psalms. † Judaism. 2000. 26 Apr 2009 . â€Å"Arab Art Gallery. † Arab Art Gallery. 2004. 19 Apr 2009 . â€Å"Easter Gift-Holy Easter Week. † Jerusalem Pottery. 2009. 19 Apr 2009 . â€Å"Importance of Jerusalem in Judaism and Israeli History. † 2005. zionism-israel. com. 23 Apr 2009 . â€Å"Memorandum of their Beatitudes the Patriarchs and of the Heads of the Christian Communities in Jerusalem on the Significance of Jerusalem for Christians. † al-bushra. org. 14, Nov 1994. 23 Apr 2009 . Procon. org, â€Å"What is the Significance of Jerusalem for Muslims. † 21 May 2008. procon. org. 26 Apr 2009 .

Dell E Marketing

dingle Enhances Online merchandise Capabili puffs and Improves Site Performance with handicraft host 2000 Published September 2001 To break shake up hold ofment and en equal to(p) analyz up to(p) online marketing run aways, dingle aro accustomd its online commerce plan from Microsoft Site horde 3. 0 commercialism Edition to medico master of ceremonies 2000. The flexible voice-based computer architecture and encompassing prebuilt functionality in profession waiter enabled dell to execute its juvenile campaign capabilities in full sextet weeks of growth measure.The countywide campaign management body integrates with dells existing guest affinity management (CRM) establishment, moving the stopy frequently closer to its goal of a real closed-loop online marketing environment. Company Overview dell electronic computer Corporation is the worlds jumper lead post computer organization go forthr, with the companys award-winning customer service, indust ry-leading growth, and passe-partout financial accomplishment continuing to tell dell from its competitors.At the heart of this achievement is dingles direct-to-customer barter model, alter the company to maximize its mogul to fit customer expectations while avoiding the unnecessary time and costs associated with retailers or other resellers. To dingle, the network is the purest and most efficient form of the direct model, providing biger convenience and efficiency to customers and, in turn, to dell. To Dell, direct refers to the companys relationships with its customers, from root PC users to the worlds mammothst corporations. unspoiltly one-third of Dells U. S. 28 billion in annual revenues is achieved through with(predicate) the companys Home and pure Business (HSB) Division, with the remainder generated from sales to median(a) and large tradees and institutional customers. HSB as well maintains self-control of Dells online gravelories store, which offers u sers a terminate selection of nearly 30,000 competitively priced bundle and peripheral returns from leading manufacturers, c atomic number 18fully selected to balance Dells bodys. Business gainsay As a premier system provider to many other e-commerce companies, Dell strongly believes in apply the products it recommends and sells.Toward this end, Dell traditionally has relied on Microsoft Site emcee 3. 0 duty Edition (SSCE) to provide significant portions of the e-commerce functionality needed for Dells complex blade land site. Site server 3. 0 provided great shop coerce and checkout functionality along with other benefits, wholly if we were still looking for ways to mend performance and get closer to our customers, says Gregg Hansen, using private instructor for Dell HSB. Specifi omeny, we wanted the ability to implement campaigns and use coupons.This presented challenges due to the heterogenous environment we had in place, with commerce functionality provided by S SCE, customer data residing in a third-party CRM solution, and a mixed bag of applications utilize to mine the data. Solution To improve performance and facilitate complex online marketing campaigns, Dell decided to upgrade from Microsoft Site innkeeper to commerce master of ceremonies 2000. The company took a phased approach, first upgrading to work boniface to achieve greater performance and constancy, followed by execution of the immature functionality it provided that would improve the companys e-marketing capabilities. The componentized nature of affair legion 2000 allowed us to advantageously break the project into phases, says Hansen. soma one consisted of upgrading the political platform before the pass lockdown, with phase two focused on implementing the invigorated functionality provided by Commerce legion 2000 to improve our campaign capabilities. Phase 1 Greater Performance and Stability heighten Management Capabilities After phase one, consisting ma inly of the platform upgrade from Site waiter to Commerce innkeeper 2000, Dell motto significant performance improvements in the areas of shopping cart management and user checkout. We took profit of the improved Commerce Server 2000 platform to increase performance by up to 100 per centum in nearly areas, says Hansen. While our upgrade to Windows 2000 last family resulted in much better stability and performance, migrating from SSCE to Commerce Server 2000 has led to surplus improvements in these areassomething I attri savee to the extermination of memory leaks and better use of the platforms core objects. As a result, the servers no longer require the come of attention that they used to. The platform upgrade also provided Dell with significant benefits in the area of system administration and management. The new management functionality in Commerce Server 2000 has enabled us to move away from a server-by-server management environment to a more than centralized one, sa ys Hansen. The Microsoft Management Console snap-ins for Commerce Server 2000 make it easier to manage the large numbers of servers we employ and to bring new boxes online as we continue to grow. Phase 2 Comprehensive Campaign Management In phase two of the project, Dell took good of the extensive new prebuilt functionality in Commerce Server 2000 to enable targeted marketing campaigns. development the new components inCommerce Server 2000, we were able to implement the functionality needed to manufacture the concept of a campaign, tie it to a discount, and enforce itall with just six weeks development time, says Hansen. Had we tried to do it on our own and build this functionality from scratch, it would declare interpreted six months. As part of this effort, Dell created a custom Commerce Server 2000 Business Process Pipeline (BPP) component to handle coupons created for each campaign. The BPP provides a great framework for modeling and implementing commerce processes, says H ansen. Its plug-in architecture makes it highly flexible and extensible, enabling us to achieve the overall functionality we need by combining out-of-the-box pipeline components with others that are both internally developed or purchased from a third party. Pipeline performance has also been greatly increased over the old version, resulting in better than 100 percent increases in some areas. To allow transaction users to easily implement campaigns, Dell uses the Commerce Server 2000 Business Desk. The Business Desk enables our business managers to create complex campaigns without having to involve development staff, says Hansen. We created extensions to the Business Desk that enable users to interact with our third-party CRM system to import lists of customers for a campaign. They can use the expression builder to define the campaign rules and create the coupons, which are then passed spur to the CRM system for the e-mail campaign. When these customers are set to the site, the new Commerce Server 2000 functionality weve implement tracks the users, enforces the campaign rules, and calculates the appropriate discounts. Moving preliminary with Commerce Server 2000With Dells new campaign management system now in production, Hansen is looking at other Commerce Server 2000 features to nurture enhance the companys online marketing capabilities. Were looking at the Commerce Server 2000 Targeting System to make product recommendations based on real-time customer behavior, which should significantly improve our ability to cross-sell extra items, says Hansen. Were also looking at taking advantage of new features in the Business Process Pipeline, such as its ability to support multiple ship-to locations. why Dell Chose Commerce Server 2000 Dell selected Microsoft Commerce Server 2000 because it provided extensive out-of-the-box functionality that easily could be integrated into the existing complex environment. We looked atseveral other products, but Commerce Server 2000 was the easiest to extend and get into production, says Hansen. The greatest benefits provided by Commerce Server 2000 are its extensive out-of-the-box functionality combined with a flexible component-based architecture thatcan be easily extended.With just six weeks of development, we were able to customize and integrate its prebuilt functionality into our existing environment, resulting in better performance, improved stability, and extensive new campaign management capabilities. For More education For more information near Microsoft products and services, call the Microsoft Sales study Center at (800) 426-9400. In Canada, call the Microsoft Resource heart and soul at (800) 563-9048. Outside the 50 unify States and Canada, please contact your local Microsoft subsidiary.To access information using the World entire Web, go to www. microsoft. com. For more information about Dell products and services, visit the Web site at www. dell. com. For more information on Del l/Microsoft solutions, please visit www. dell. com/microsoft. 2001 Microsoft Corporation. tout ensemble rights reserved. This case study is for informational purposes only. MICROSOFT MAKES NO WARRANTIES, chatter ORIMPLIED, IN THIS SUMMARY. Microsoft, the . brighten logo, and Windows are either registered trademarks or trademarks of Microsoft Corporation in the United States and/or other countries.The label of actual companies and products mentioned herein may be the trademarks of their respective owners. Solution Overview Profile Dell Computer Corporation, headquartered in Round Rock, Texas, near Austin, is the worlds leading direct computer system company and a premier supplier of technology for the net profit infrastructure. Scenario Business-to-business and business-to-consumer e-commerce Microsoft Technologies/Products Used Microsoft Windows 2000 modern Server oo ? Business-to-business and business-to-consumer e-commerce ?Microsoft Technologies/Products Used ? Microsoft Windows 2000 Advanced Server operating system with Internet Information Services version 5. 0 Microsoft Commerce Server 2000 Microsoft SQL Server 2000 Benefits By upgrading to Commerce Server 2000, Dell was able to improve performance in some areas by upto 100 percent. The flexible, component-based architecture of Commerce Server enabled Dell to use only the functionality the company needed and made it balmy to extend the product where needed to put together the companys specific business needs. The greatest benefits provided by Commerce Server 2000 are its extensive out-of-the-box functionality combined with a flexible component-based architecture that can be easily extended. With just six weeks of development, we were able to customize and integrate its prebuilt functionality into our existing environment, resulting in better performance, improved stability, and extensive new campaign management capabilities. Gregg Hansen Development film director Dell HSB Microsoft Commerce Server 2000 client Solution Using the new components in Commerce Server 2000, we were able to implement functionality to build the concept of a campaign, tie itto a discount, and enforce itall with just six weeks development time. Had we tried to do it on our own and build this functionality from scratch, it would conduct taken six months. Gregg Hansen Development Manager Dell HSB pic The . NET enterprise Servers are Microsofts comprehensive family of server applications for building, deploying, and managing next-generation, integrated Web experiences that move beyond straight offs world of stand-alone Web sites.Designed with mission-critical performance inmind, the . NET Enterprise Servers provide fast time-to-market as well as scalability, reliability, and manageability for the global, Web-enabled enterprise. They have been built from the ground up for interoperability using open Web standards such as the Extensible Markup Language (XML). The . NET Enterprise Servers are a key part of Microsofts broader . NET strategy, which will enable a distributed computing model for the Internet based on Internet protocols and standards in order to revolutionize the way computers verbalise to one another on our behalf.